Congress detail

Authors: Ponce, Sergio; Arce, Debora; Tapia, Elizabeth; Pratta, Guillermo.

Resumen: Small heat shock proteins (sHSPs) are low molecular weight (12?40 kDa) chaperones that havebeen associated with stress tolerance by preventing irreversible aggregation of misfolded proteins.Abiotic stress and developmental changes trigger sHSP gene expression and protein synthesis inall living organisms, suggesting the existence of a complex chaperone-network to maintain cellularhomeostasis after heat stress (HS) exposure. The acclimatization process is characterized by theexposition to mild HS (35-38 °C) before severe HS (41-45 °C) exposition and is related to chronicadaptation to abiotic stress conditions. However, acclimatization might be involved in theadaptation of plants and animals to global warming. Identifying key regulatory and masterregulators during this process might contribute to agricultural and medical areas for betterbreeding programs coping with global warming. In order to describe which are the possiblestrategies developed by different organisms to face HS, we made an exhaustive bibliographycuration process to identify experiments of HS, in the presence or absence of an acclimatizationprocess. After assigning the corresponding Uniprot ID of co-regulated genes up-regulated in unacclimatedand acclimated HS organisms, predicted protein-protein interaction analysis (PPIs)were performed using the STRING database. We identified similar gene chaperone network members, mainly represented by HSPs: HSP100, HSP90, HSP70, and sHSPs. Notably, a conservativesubset of sHSPs is shared between co-expressed genes during HS in different model andnonmodel organisms (human, drosophila, wheat, Arabidopsis, rice, tomato, and potato).Particularly, at least one of each mitochondrial, chloroplastic and cytosolic class I sHSPs, werepresent in all datasets analyzed. Despite small variations in their order of appearance, HSP90,HSP70 and HSP100 proteins were identified and constitute the first barrier or fence in responseto HS conditions in different organisms. Our findings suggest that a conservative subnetworkcould be involved specifically during acclimatization in living organisms.

Meeting type: Congreso.

Type of job: Resumen.

Production: Protein subnetworks involving sHSPs during acclimatization process in living organisms.

Scientific meeting: World Congress on Medical Physics & Biomedical Engineering 2018.

Meeting place: Praga.

Organizing Institution: IUPESM-International Union for Physical and Engineering Sciences in Medicine.

It's published?: Yes

Publication place: Praga

Meeting month: 6

Link: here